In the wake of an unspeakable tragedy, Erica Kravid puts her dark plan into motion with Renautas. Hiro and Angela are tasked with an important mission that could change the course of humanity. In Odessa, a distraught Luke and Joanne come to realize their tragic mission after the loss of their son. Meanwhile, Noah Bennet has an unexpected reunion with Matt Parkman. In Japan, the origins of Miko come to light. Elsewhere, the truth behind Carlos’ military service is revealed.
When things take a turn for the worse with Sara, Oliver calls in a favor from an old friend who deals in the mystical, John Constantine.
When Brian calls in sick for a day off from the FBI, the CIA abducts him from home to borrow his NZT-enhanced capabilities for a black ops mission. As the operation becomes increasingly dangerous, Brian finds himself without FBI support in a situation that’s spiraling out of control.
The stakes get even higher as Hunter and May continue to go after Ward and Hydra, and Daisy and Coulson begin to suspect that the ATCU may be keeping a big secret from S.H.I.E.L.D.
Barry learns a new breacher, Dr. Light, has come through the portal and sets off to capture her. Jay tells Barry that Dr. Light was not a threat on Earth-2 and that Barry can reason with her. However, during a fight with The Flash, she blinds him and drops some shocking news about Zoom. Meanwhile, Barry and Patty go out on a date.
Jason uses aggressive investigative tactics while working on a student loan case with Alicia and Lucca. Howard points to Cary as the primary offender when he alleges ageism at Lockhart, Agos & Lee. Eli creates drama among the Florricks.
The hacktivists rise up; Quinn covers for Carrie; Dar and Allison assess the damage.
In an effort to get answers, Noah Bennet joins forces with Hiro Nakamura to return to the day of the tragic events of June 13, 2014 that set everything in motion. On the verge of delivering a speech to commemorate the event, Mohinder Suresh receives a dire message from Angela Petrelli about Erica Kravid’s true motives. In Japan, Hachiro Otomo makes a calculated move against Hiro Nakamura. Meanwhile, a much happier Luke and Joanne come to Odessa in hopes of finding a cure to their son’s ailment.
Laurel must deal with the repercussions of taking Sara to Nanda Parbat. Meanwhile, Oliver asks Captain Lance for a favor and while he’s not surprised at the response, he is surprised at what he finds out next.
When Brian begins to experience the side effects of NZT again, Senator Morra demands he betray Rebecca in exchange for another inoculation. Also, Brian secretly looks for an alternate cure for himself while he works with Rebecca outside FBI parameters to find the creators of NZT.