When Naz is detained on suspicion of funding terrorism, Brian and Rebecca’s efforts to clear her name lead them to Naz’s daughter, Ava, who reveals a family secret Naz is keeping from the FBI.

As Daisy and the team fight to protect Inhumans, S.H.I.E.L.D. discovers the shocking truth about one of their biggest foes. Meanwhile, Fitz helps Simmons recover information that could lead them back through the portal.

After recent events, Barry decides it’s time to confront Zoom and comes up with a dangerous plan. Caitlin sides with Jay and deems it too dangerous for Barry to engage with the speed demon. However, Iris shows her support and brings forth a surprising ally. We see what Earth-2 Harrison Wells’ life was like before coming through the breech.

Detective Slaughter returns to enlist Castle’s help in solving a high-stakes robbery case. But when a body is found linked to the crime, Slaughter becomes the number one suspect in the heist turned murder, while Castle has to determine whether he’s guilty or help to prove he’s innocent.

Saul orders a sweep at the station. Carrie looks to Düring for support.

Alicia and Lucca defend a former technology firm employee who was fired after failing a polygraph test. Eli wants to leak information that would damage Peter’s campaign—but could also impact Alicia.

In the wake of an unspeakable tragedy, Erica Kravid puts her dark plan into motion with Renautas. Hiro and Angela are tasked with an important mission that could change the course of humanity. In Odessa, a distraught Luke and Joanne come to realize their tragic mission after the loss of their son. Meanwhile, Noah Bennet has an unexpected reunion with Matt Parkman. In Japan, the origins of Miko come to light. Elsewhere, the truth behind Carlos’ military service is revealed.

When things take a turn for the worse with Sara, Oliver calls in a favor from an old friend who deals in the mystical, John Constantine.

When Brian calls in sick for a day off from the FBI, the CIA abducts him from home to borrow his NZT-enhanced capabilities for a black ops mission. As the operation becomes increasingly dangerous, Brian finds himself without FBI support in a situation that’s spiraling out of control.

The stakes get even higher as Hunter and May continue to go after Ward and Hydra, and Daisy and Coulson begin to suspect that the ATCU may be keeping a big secret from S.H.I.E.L.D.