Brian risks his new FBI job when he disobeys orders to stay out of the investigation into a renowned journalist’s murder.

When Coulson and the team discover a new Inhuman, S.H.I.E.L.D. comes face to face with another organization searching for powered people. And still reeling from Simmons’ dramatic disappearance, Fitz goes to extreme lengths to try to learn how to get her back.

In part 2 of the premiere, Beckett’s side of her abrupt disappearance is revealed. After receiving a mysterious tip from her past, Beckett is launched into a fight for her life, with a team of mercenaries hot on her trail. While Castle investigates why his wife is on the run, Beckett must figure out who wants her dead, before they can finish the job.

Kiera and Brad’s trust reaches a breaking point; Carlos and Kellog come to their own realizations; Alec has a strange encounter.

After a terrorist attack in Odessa, Texas, left the city decimated and lives in shambles, those with extraordinary abilities are in hiding after being blamed for the catastrophic event. A new world order has them being hunted by those with nefarious motives, such as Luke and Joanne Collins, who are out to avenge a tragic loss of their son. Meanwhile, Noah Bennet has taken measures to put his old life behind him and start over, until he comes face to face with Quentin Frady, a conspiracy theorist out to uncover the truth behind the Odessa tragedy. Elsewhere, some are discovering their newfound skills. Awkward teen Tommy just wants to be normal and win the girl of his dreams, Emily, but normalcy is virtually impossible after learning of a new ability that terrifies him. Coming from a very sheltered upbringing, a bold and ethereal teenager, Malina, has been told she is destined for greatness. In Tokyo, a quiet and unique young woman, Miko, is trying to track down her missing father while hiding an extraordinary secret that will make her a force to be reckoned with. In Los Angeles, a different type of hero is emerging through former soldier Carlos. For better or for worse, some are fated to cross paths with assorted heroes of the past and together their ultimate destiny is nothing less than saving the world and mankind.

Those with extraordinary skills continue to adapt to their discovered powers and a new world order in the wake of a terrorist attack in Odessa, Texas.

Haley gets back together with Dylan. Alex and Sanjay plan their breakup since they are both going off to college. Mitchell avoids finding a new job and takes up art. Jay and Gloria try to find a good preschool for Joe.

Brian Finch’s life takes an extraordinary turn when he uses a mysterious drug, NZT, that allows him to access his full brain capacity. However, when an NZT-related murder lands Brian on the FBI’s radar, he uses the drug in an attempt to stay ahead of the authorities long enough to clear his name.

After passing the Captain’s exam last season, Beckett was surprised with an offer to run for State Senate. In the action packed season premiere, Castle and Beckett are adjusting to Beckett’s career change, when a call from a mysterious stranger sets off an explosive chain of events. There are two sides to every story, and this unique two-parter will explore the same story from each of their perspectives, first from Castle’s side as he searches for Beckett.

Alec joins Carlos and the VPD; Kiera and Garza form an alliance.