It’s Career Week at school. As Kyle and Josh contemplate their respective futures, Jessi’s quest for acceptance clashes with Kyle’s need for anonymity. Meanwhile, Brian Taylor seeks parenting advice from Nicole.
When an unassuming high school chemistry teacher discovers he has a rare form of lung cancer, he decides to team up with a former student and create a top of the line crystal meth in a used RV, to provide for his family once he is gone.
An automated lockdown traps Atlantis personnel in various parts of the city, each of them hoping the others will come to their rescue.
Sona’s Commander General Zavala takes Michel and locks him in a « hot-box » in solitary confinement to be punished by law or by Panama’s sun. Meanwhile Agent Lang brings Mahone back to Sona and gives an amulet to him that belonged to her father. Michael decides to tell the truth to General Zavala and he brings Whistler, who is submitted to torture and gives the name of Gretchen Morgan. Meanwhile Lincoln is blindfolded by Gretchen and has one minute of conversation with L.J. T-Bag proposes Mahone to kill Sammy; in return he would supply drugs for free for him. Bellick is challenged for a fight and he uses acetone to defeat his opponent. Gretchen is arrested and tortured by General Zavala and she gives the location of L.J. However she manages to revert the situation and kills Zavala. Augusto gives a pistol to Sammy and tells him that it is time to make a move.
Believing Jessi is dead, Kyle returns to the Tragers and reveals the truth about Madacorp. He’s now determined to take down MadaCorp and destroy all the information they have on Zzyzx.
The team finds their former Wraith ally’s hive ship drifting in space, which leads them to a secret project that could turn the tide of a civil war.
Earl is having difficulty re-adjusting to life on the outside. He returns to his old ways after he encounters Ralph. Randy plans an intervention for Earl on Christmas morning.
With a plan to potentially extinguish the Replicator threat, the Atlantis team must seek an alliance with a fleet of Wraith ships.
Chuck learns the most shocking secret of her life and refuses to forgive Ned. In order to take the Pie Maker’s mind off of Chuck, Emerson gets him to solve the mystery of a man killing life insurance agents and hiding them in snow banks. Oscar Vibenius returns to investigate why Chuck has an unique smell. Meanwhile, the aunts’ antidepressant-laced pies begin to show some hallucinogenic effects.
Ted’s upcoming date with his doctor leads the gang to give him their own examples of why dating someone you already see regularly is a bad idea.