Nothing is too big when Phil and Claire decide to throw Luke the biggest and best birthday party a boy could ever want, but when Cameron shows up as Fizbo the Clown, it sets off a chain of events that ends with someone in the hospital.

Frankie’s plan to have an idyllic family Thanksgiving backfires when Mr. Ehlert demands his staff work over the holiday. Brick goes missing in a corn maze.

Erica works with new allies to uncover a biological threat they suspect the Visitors have been plotting. Aboard the mothership, Anna meets with a special guest, while managing the investigation into the murder of a V. Chad does a segment on the V Healing Centers demonstrating their amazing medical abilities, but finds himself conflicted by some of his findings.

H.R.G. hosts an untraditional Thanksgiving dinner. Elsewhere, the Petrelli family gets a surprise guest at their table. Meanwhile, Samuel continues to hold Hiro hostage, as Lydia goes in search for the truth.

Aboard Destiny, Dr. Rush supervises the exploration of new areas of the ship. Looking for resources to make their everyday lives easier, the crew stumbles upon a piece of Ancient technology that carries the promise of a way home. While somewhat familiar with the find, Dr. Rush can’t guarantee the safety of using it, bringing him and Col. Young to a standoff on what to do.

The CBI team is faced with a violent and shocking crime in their own office, but must work the case in spite of their alarm of who may be behind it. Meanwhile, Rigsby and Van Pelt are definitely an « item ».

Jeff is tasked with telling Senor Chang that he assigns an unreasonable amount of homework. Troy and Abed lose their subject for a biology lab experiment.

With a history of giving bad gifts, Claire is determined to surprise Phil with an amazing anniversary present: a private performance by one of their favorite musicians, Izzy LaFontaine (Edward Norton). However, it turns out to be unexpected in more ways than one. Meanwhile, Mitchell and Cameron call up their « party-girl bestie », Sal (Elizabeth Banks), for a long overdue night out on the town.

While Alicia is preparing in a case defending a scientist accused of arson, she is suddenly asked to testify on Peter’s behalf.