Erica, Father Jack and Hobbes realize that the V’s know names and addresses of The Fifth Column members and must take drastic measures to protect them while, Ryan finally reveals to Val that he’s a Visitor. And Chad, with the camera rolling for « Prime Focus », begins the process aboard the Mothership’s Medical Bay to have his aneurysm removed.

President Taylor faces impossible choices, and, much to the dismay of CTU, she enlists a private security firm to complete a sensitive task led by Mark Bledsoe. Meanwhile, Jack calls in a favor to his old friend Rick Vickers before embarking on a crucial mission of his own.

The episode focuses on Nicholas Rush, who risks his life from an experiment involving the ship’s computer, and flashes back to the time when he was recruited into the Stargate Program. His now dead wife, Gloria Rush, will be appear in these flashbacks, as will Michael Shanks as Daniel Jackson.

When Patrick Jane’s sneaky conduct causes the case of a confessed hitman to be tossed out of court, his annoyed CBI team must start the investigation over from scratch.

When two teenagers on a date turn up « dead » at an abandoned warehouse with the three puncture wounds to the soft palate — a trademark of the shape-shifters — the Fringe team investigates the evidence as well as the motives of mastermind Newton. Upon discovering a shape-shifting embryo, Walter returns to the lab to conduct further analysis, and Olivia and Peter head to Massive Dynamic for answers. Meanwhile, Peter reveals a family secret to Olivia as Walter struggles to recall what Newton knows about « building a door ».