Sylar continues his unusual partnership and begins to have an unexpected identity crisis. Hiro and Ando take measures toward bringing down Building 26. Meanwhile, Matt’s new found fatherhood changes his priorities. Elsewhere, Nathan sets a plan in motion to right the wrongs of his government operation.
As the nation remains vulnerable, Jack Bauer endures the worsening pathogen pain. The FBI deals with recent deadly developments while matters involving key players takes this day into a unexpected direction.
Rumors fly about Jesse’s recent actions as he and Walt discuss expanding their business into new territories. Hank struggles to fit in with his new co-workers in El Paso. Skyler pursues a new job opportunity that reconnects her with a former colleague. Jesse gets to know his landlord, Jane.
Michael and Sara journey to Miami while Lincoln meets with his mother. T-Bag and Self’s mission to locate Scylla takes a dramatic turn. The General comes under pressure.
Randy busts into the motel room, demanding that Earl drive to Joy’s and punch her in the face. Over time, Randy has invested lots of time and money in the Crab Shack’s claw machine, but every time he wins a cute stuffed animal, Joy bullies him into giving it to her. This last time he won a fancy bird dressed up for a wedding and the loss has put Randy over the edge. Earl points out that Randy is 32 years old, and it’s time he learned to stick up for himself – Earl’s not going to protect him anymore.
An exotic visitor sparks mixed reactions in the firehouse. Tommy deals with the possibility of expulsion from the FDNY and a new sponsorship role in AA. As Mike and the guys renovate their new bar, Sheila learns that being a big sister isn't always easy.
As animal rights activists ransack a laboratory, they get more than they bargained for when one of the caged “animals” unleashes a ferocious appetite. Leaving grotesquely mutilated dead bodies in its wake, the scientifically engineered beast with the body of a lion, claws of an eagle, fangs of a viper, skin of a rhinoceros and tail of a serpent attacks Charlie. With Charlie’s life on the line, Walter must come face-to-face with both his past and the beast.
Castle and Beckett look into the Vudon religion when an immigrant is found tortured in a ritualistic killing. Meanwhile on the homefront Castle must deal with the possible homecoming of Alexis’ mother, his first wife.
Ted goes out on his own as an architect and hires an intern to help get things started, but the intern gets a little too close to others in the gang.
As Nathan, Claire, Peter and H.R.G. help Angela uncover her past, she reveals the dark secrets that have haunted her for years. Meanwhile, Mohinder learns of his father’s involvement in a long forgotten government operation.