The fallout from the nuclear blast in Denver will hit Jericho in an hour and Jake has to get the residents inside. The official shelter is not adequate and Jake must find another shelter to protect them. Emily faces troubles of her own while being picked up by who she thinks are two officers.
After a nuclear disaster caused by several terrorist attacks wipes out most of North America, residents of a small Kansas town have to come to terms with a very different reality.
Strange behavior is affecting the whole town except Sheriff Carter and Zoe. The father and daughter team must find the cause while Stark makes a decision that could affect the world.
Michael and Linc arrive in Tooele, but the map they need to locate the double-K ranch is missing. They run into T-Bag and Tweener, who have also come to Tooele for Westmoreland’s money. Meanwhile, C-Note makes his way by train toward Tooele. Sucre reaches Las Vegas and attempts to halt the wedding of Maricruz and Hector. Sara invites Kellerman to her apartment, believing he is harmless. At the FBI office in Chicago, Mahone reviews files recovered from Michael’s hard drive, and begins to piece things together.
The gang tries to help Marshall get over Lily, especially when he finds a credit card bill that leads to a hotel in New York City where some of her charges are listed.
Sheppard and Ronon are influenced by a mind-altering device created by the Wraith while on a mission to rescue a lost team.
Cameron Mitchell must go undercover inside the deadly Lucian Alliance to prevent his teammates from becoming casualties of an Alliance civil war.
Fargo invents a device that bridges the gap between computers and human brains
Michael, Linc, and Nika are captured by Bellick and Geary, who intend to retrieve Westmoreland’s money in Utah. Tweener continues his drive with Debra Jean. Abruzzi is reunited with his wife and children and is set to flee the country with them, but decides to take care of Fibonacci first. T-Bag has a close call with the police at a Nebraska gas station, and then poses as a Marine who lost his hand in Iraq. Mahone waits for confirmation of the deaths of Michael and Linc in the car explosion, and meanwhile gets a lead on one of the other fugitives. Kellerman (posing as a recovering addict named Lance) befriends Sara.
Rodney McKay is reunited with his estranged sister back on Earth, who has given up a brilliant career as a scientist to raise a family.