A new Stargate team embarks on a dangerous mission to a distant galaxy, where they discover a mythical lost city — and a deadly new enemy.

Everyone on Earth is excited about a comet passing by, but as soon as its trajectory changes to a collision course, everyone starts to panic. The comet turns out to be a giant ball of light that, after exploding, leaves behind 4400 people. They are missing persons who have been gone from a few months to 60 years, and none have aged a day. The 4400 are put in quarantine and eventually released. Some of the returnees begin to exhibit strange and uncontrollable new abilities. Tom Baldwin and Diana Skouris, two Homeland Security agents, are appointed to find out what happened to the 4400.

While the Goa’uld threaten to attack Earth, SG-1 and the Asgard make a last, desperate stand against the Replicators, which have captured Major Carter and invaded the last outpost of the Asgard civilization.

Carter and Teal’c go in search of the Asgard to try and save Colonel O’Neill, but discover that the Asgard’s enemy has returned with a vengeance. The System Lords seek an alliance with Earth against a common enemy.

Jack and Chase must make a powerful sacrifice when dealing with the virus.

Tony is able to help Jack one last time before he is taken into custody, while an angry victim seeks vengeance on Saunders.

Palmer makes a surprising career choice in the wake of Sherry’s death.

Jack pushes the envelope in an attempt to force Saunders to disclose the location of the missing vials.

Sherry meets with David to discuss her terms, while Wayne breaks into her home to find the incriminating evidence.

Tony finds himself facing a harsh penalty because of his efforts to save Michelle.

Jack and Tony clash as the time for the hostage exchange draws near.

Keeler meets with Palmer and demands his resignation, while Wayne begins a secret operation against Sherry.

Tony works to free Jane from CTU before Saunders can harm Michelle, but Chloe and Jack become suspicious of his activities.

Sherry meets with Palmer’s political rival and proposes a deal to blackmail him.

Jack attempts to use Saunders’ daughter as leverage to gain control of the virus, while Palmer must deal with the discontented press.

Michelle gets the results of her test, while Adam finds that the virus has struck too close to home.

Tony finds himself compromised when Saunders exploits his only weakness.

Jack reluctantly works with Kim on an under-cover job that may help them gain an advantage over Saunders.

Palmer informs his cabinet of the crisis, while Saunders makes yet another demand.

Chase tracks down the man who left the hotel and learns that the virus is spreading to the general public.