Earl goes for #44 on his list trying to help Pierre, a French foreign exchange student, he made fun of when they went to school together. Earl flies him back to the US and he tries to hook Pierre up with a girl he had a crush on as a child. Meanwhile, newlyweds Randy and Catalina find their marriage changes in ways they would never imagine.
In Cutback, Montana, Kellerman lures the police and Michael and Lincoln abduct the cameraman Greg of Fox News and succeed in escaping from the siege. Michael and Lincoln decide to tape a message to be released in the Breaking News. Mahone is back in Chicago and analyzing the message; he interrogates Greg and he tells that he had overheard Michael tell that they should cover 460 miles in six hours. Mahone deducts that they intend to meet President Caroline in Denver. Wheeler discusses with Mahone and yells that the internal affair asked him to follow all moves of Mahone. Bellick is badly wounded in the infirmary of Fox River. Sucre befriends an old passenger in a bus to Ixtapa; however the driver asks him to leave the bus in a small town and Sucre robs the Volkswagen of the old man. In Algoma, Winsconsin, Haywire befriends a young couple and the girl has bruises on her arm; she tells that her abusive drunken father uses to beat her.
Hiro continues to search for a sword while being chased by mysterious figures. An invisible man named Claude has something to teach one of the heroes. D.L. takes on new family responsibilities, and Matt opens up to his wife. H.R.G. continues to focus on the captive Sylar. Claire seeks out the Haitian and then her birth parents. Mohinder looks for those on the list, and receives a surprise visitor. A psychiatrist offers to help Niki.
Jack forces Graem to take him to McCarthy’s office in the hopes of finding a lead to their father’s whereabouts. Lennox plays a trump card that removes Karen from his path as he prepares to implement more extreme policies. The FBI’s sting operation with Walid goes terribly awry, while Nadia finds herself impeded by new security measures at CTU.
Now onboard Galactica, Baltar faces charges of treason. He contemplates suicide with the help of Number Six. Questions remain about his true identity. Is he a Cylon or isn’t he? Apollo shows off the new drinking establishment on Galactica, Joe’s Bar, to Tyrol. Apollo thinks about Kara and wonders whether his marriage to Dee is worth saving.
Michael and Lincoln escape with Kellerman, who crosses a road block using his badge, and they fly to Blackfoot, Montana, to meet Terrence Steadman. In Fox River, Bellick is having a hard time especially with Banks and his gang. In Ness City, Kansas, T-Bag meets Susan and her children; when she tries to kill him, he ties the whole family to chairs. In Mound City, Nebraska, Dede is missing her mother and C-Note is trying to contact her. Mahone is alive in a hospital in Albuquerque; when Mahone tells that he is out, Bill Kim hits his son with a car to intimidate him. Mahone leaves the hospital and calls him telling that he is back. Kellerman, Michael and Lincoln abduct Steadman and Kellerman kills the two bodyguards. However, they realize that Steadman is actually a John Doe, since his existence has been erased by the Company. Michael decides to call the press to turn himself in with tragic consequences.
When Ted is constantly insulted by his former boss, who is now working for him on a project, he is told to fire the man, but he finds that a hard thing to do. Meanwhile, Barney offers Lily a lot of money to paint a nude portrait of him.
Matt reveals his abilities to his wife. HRG confers with Mohinder. Now that she knows the truth, Claire tries to make sense of her life. Hiro seeks the sword that he is destined to own. Niki must face the consequences of her decision to turn herself in to the police. Simone and Nathan are worried about Peter, who has been in a coma for two weeks. Peter meets a new hero. Micah visits his mother.
Wayne prepares to talk to the nation as L.A. deals with the fall-out from the nuclear blast. Fayed tries to set up a deal with a new trigger man who can help with the four remaining bombs. Sandra is outraged when the FBI forces Walid to wear a wire in the hopes of gaining information from his fellow inmates. Assad provides CTU with a lead, but Jack finds that it takes a personal twist when he learns that the terrorists may have connections to his estranged family.
D’Anna/Number Three squares off against Adama over the Temple of the Five. Athena asks for Helo’s aid in her plan to rescue Hera. On the algae planet, Apollo orders Dee to leave her defended position in order to save Kara. Anders helps Apollo to hold off the Cylon Centurion attack. Another copy of D’Anna finds the Temple and continues her search for the identities of the Final Five. Her messianic complex begins to concern the other Cylons.