The crew faces more than accustomed when rescuing a man from his burning apartment; Sean has a request for Maggie’s dad; Franco thinks his new girlfriend is hiding something from him; and Tommy realizes that his crew’s future together may be in jeopardy.
Jack Carter accidentally shoots Henry while suffering from short-term memory loss, meanwhile a visit from a noted scientist may hold clues into to his sudden memory loss.
Kyle becomes frustrated when he experiences his first brief flashes of memory, and he ultimately finds comfort from Amanda. It’s the day of Lori’s birthday, but she’s not excited about it while Kyle on the other hand, wishes he even knew the date of his birthday.
Kevin Burkoff becomes a marked man when his research on promicin is discovered. When Tom and Diana search for him, they discover how far he will go to protect his work. Shawn meets his idol at the 4400 Center.
Sheppard’s team meets an obnoxious man who is adored by all thanks to a secret that he carries — and who has an unexpected effect on them.
Daniel and Vala travel to Atlantis in search of Merlin’s anti-Ori weapon, while Sam, and Mitchell join forces with Dr. McKay to lock out the Ori supergate.
Lou turns to new-age techniques in his efforts to change his life. Sean and Maggie come to a surprising decision. Tommy and Angie continue to see each other, which quickly leads to an embarrassing scene with Janet.
Carter and the other citizens of Eureka attend the funeral of Susan Perkins. Much to their surprise, Ms. Perkins makes a return to Eureka as a woman who is very much alive!
Kyle, Lori and Josh experience difficulties on the first day of school while Nicole and Stephen receive a visit from Tom Foss.
Tom and Diana are drugged with a hallucinogen, that was created from oil that was secreted from the hands of a 4400.