When an old family friend, Jessica Danforth, tells Oliver and Thea that she is going to run for mayor, both Queens are concerned considering the last three mayors have been murdered. Despite their protests, Jessica makes her announcement so the Green Arrow and Speedy vow to protect her. Meanwhile, Thea begins to exhibit effects from the Lazarus Pit. In addition, Felicity is faced with a tough business decision and looks to one of her employees, Curtis Holt, for help.
Brian’s loyalty to the FBI is tested when Sands, Senator Edward Morra’s representative, demands he steal the FBI’s secret files on NZT. Also, Agent Harris is emotionally conflicted when she learns what her estranged father left her following his death.
Daisy, Mack and Coulson race to protect Lincoln as Rosalind’s team hunts down the Inhuman in their quest for powered people. Meanwhile, Hunter proves that there is no line that he will not cross to exact his revenge against Ward and Hydra.
Jay Garrick, a mysterious man from Earth-2, appears at S.T.A.R. Labs with a dire warning about an evil speedster named Zoom, who is set on destroying The Flash. Barry and the team must decide if they can trust this stranger even as they face yet another powerful meta-human. Meanwhile, Joe must deal with a determined officer named Patty Spivot who wants to join his meta-human task force.
When Castle’s idol, a famously reclusive author, turns up dead, Castle is determined to solve his hero’s murder. But as he and Beckett dig deeper, they discover that truth is stranger than fiction.
Carrie and Düring visit a refugee camp. Saul and Allison are at odds. Quinn stays on mission.
Alicia argues a complex museum vandalism case that involves photographs taken by a mother of her son, and considers enlisting the help of investigator Jason Crouse. Meanwhile, Cary deals with inappropriate conduct towards some younger associates at the firm by partner Harold Lyman.
Series Finale: Kiera and Alec risk everything to stop the future soldiers and their devastating plan. Kellog, despite a loose alliance with Kiera, has plans of his own. All factions clash violently in order to determine which path the future will take.
In search of someone from his past, Noah breaks in to Renautas for answers. Miko continues her rescue mission and travels in search of her sword. Tommy must use his ability to save the life of someone close to him. Luke comes up against unexpected obstacles in his relationship with his wife. Carlos takes major steps forward in his heroic journey.
Mitchell takes a job with a rival of Jay’s; Luke and Manny visit Alex but use the opportunity to meet girls; Gloria is upset when a cheerleader doesn’t decorate Manny’s locker; Phil and Claire try to play chicken when Dylan moves in.