Jack and Chase quarrel over Chase’s relationship with Kim. Meanwhile, they learn of a lead to the possible whereabouts of the virus after rading a crackhouse.
Linda breaks up with Kyle when she learns that he is planning to make a drug delivery.
Wayne approaches Palmer with information about his girlfriend that could damage his chances for reelection, while a CTU employee is not what he seems.
Three years have passed since the events of Day Two. A van deposits a dead body outside the LA Health Unit. The body is infected with a deadly virus. Tony, now in charge of CTU, learns that this is a blackmail tactic to get the US government to release a drug lord, Ramon Salazar, whom Jack has just brought down, before Salazar’s brother releases the virus into LA.
Jack and his new partner, Chase Edmunds, prepare to sign a deal with Salazar at the prison. Salazar delivers a mysterious warning to Jack before killing his lawyer.
Palmer is alive and well, and has returned to LA for the first time since the attack three years ago. He is running for re-election and is preparing for an important debate with a rival senator. He is accompanied by his brother, who happens to be his chief of staff and his doctor, who also happens to be his girlfriend.
A young boy, Kyle Singer, is seen examining a large, mysterious bag of white powder. He plans to deliver it to some dealers later that day, but he is being watched by Salazar’s men.
Kim now works at CTU and has been dating Chase for three months. Kim wants to tell her father, but Jack has a mysterious health problem that may make things more complicated.
On the first anniversary of George’s death, Rube grants her the day off. Motivated to get her afterlife on track again, she returns to Happy Time to ask for her old job back. But after being bluntly rejected, George pouts through yet another drab day…until the universal powers-that-be intervene and inspire her to try to live her afterlife to the fullest.
Death takes the day off. So Rube recruits the reapers to help him with some clerical work. As the soul-takers file their victims’ last thoughts, they all realize what truly mattered to them in life. Especially George, who fondly remembers the summer vacations she spent with her family at the lake.
Taking souls is taking its toll on George. Unable to sleep, she wanders to the Waffle Haus, where she’s angry to find she wasn’t invited to take the self-examination test currently occupying the other reapers. But George’s anger quickly turns to panic when she learns that Rube has an assignment to take a soul at her family’s house that night!
George can’t afford the new bicycle she wants so she gets a new job. Immediately, coworkers at her old job begin planning a farewell party. Meanwhile, Mason mingles with a gay couple and Daisy is stalked by the soul of a passionate painter. Soon, the reapers begin to realize just how important a part they play in people’s lives.
As Daisy talks both George and Mason into swindling one of her wealthy victim’s sons out of a lot of money, and Roxy mourns the anniversary of her own death, Rube keeps a careful eye on his minions. Soon, the con is on and the grief is great…and Rube’s got valuable lessons about the afterlife for all.
An assignment leads George to a college campus, where she befriends a fresh-faced coed with a curious fascination for a literature professor…who just happens to be George’s dad! Sitting in class with her new friend, George gets to know her dad – and herself – in a way she never did in life.
The team investigates an unstoppable new enemy soldier engineered by Anubis. Dr. Jackson leads a team in search of an alien device in Central America, but gets more than he bargained for.
When George decides to care for the beautiful golden retriever her latest victim has left behind, and Rube steps in as a grill cook to replace the man whose soul he recently took, both find themselves feeling lost and out of place. but as they boldly face their predicaments head-on, the two reapers finally figure out where they belong.