A serial killer dubbed The Scalper' is attacking blonde women, including a friend of Tessa's. MacLeod recognizes the pattern of an Immortal who, betrayed by the woman he loved, became a killer. To end the carnage, MacLeod was forced to confront and kill him, back in 1925. Now the killings have started again, the modern day killer mimicking the 70-year-old M.O., killing in the same locations as the previous murders. It falls to MacLeod and Tessa to stop this madman.

Seeking revenge for the apparent death of her lover, Walter Reinhardt, Rebecca Lord toys with MacLeod before she attempts to kill him with Reinhardt's sword. Rebecca knows nothing of Immortals or their combat, and she believes MacLeod murdered Reinhardt. Unbeknownst to her, Reinhardt is still alive, and is using Rebecca in a cat and mouse game to draw out MacLeod for their final confrontation.

Richie Ryan tries to protect an old girlfriend, Nikki, from a band of drug dealers. This puts them both in jeopardy from an Immortal, Voshin, whom MacLeod knows from an adventure during the Second World War when he was trying to smuggle Jewish refugees out of occupied Eastern Europe. Nikki complicates the story by withholding drug money she has stolen from the gang, thinking she can use it to make a better life for her small daughter. Tessa, meanwhile, becomes enamored of the child, raising issues for her and MacLeod.

MacLeod is struck and "killed" by a speeding automobile. When he revives in the hospital, he attracts the attention of a deranged doctor, who kidnaps MacLeod for his research on a miracle cure for trauma. When MacLeod escapes from the doctor, the doctor murders a potential witness and frames MacLeod for it.